With the rapid progression of sensor and wearable communication technologies (e.g., smart watches, fitness trackers, and sleep monitors), Internet of Things (IoT), and machine learning techniques, smart technology solutions have the ability to transform healthcare from reactive to preventive, proactive, and decision-based. Innovations such as remote patient monitoring, telemedicine, real-time air quality information, infectious disease surveillance, data-based public health interventions, and integrated patient management systems can significantly impact quality of life and long-term health outcomes. Researchers at UTC have launched a health-centric urban mobility research initiative that blends health, transportation, environment, urban science, computer science, social science, computational science, and data science to identify innovative, sustainable, and economically viable options to improve quality of life. UTC is also leading the mStroke initiative, which is using wireless sensor technology to establish a remote extended monitoring and mobile health system for risk-related stroke measures to proactively provide patients, caregivers, and health professionals with real-time data at the body structure, activity, and participation levels to support stroke patients’ optimal long-term recovery.